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Drug Discovery and Development

Research, discovery, and development of new medical drugs and treatments.

The Costly Game of Drug Discovery
Only about 30 new drugs are approved each year and each costs several billion to develop. How are these new medicines identified and why is it so expensive? Here's an overview of how drug discovery works and how it has changed in recent years (Posted: Jan 31, 2014)

Pressure from Patients and Payers Is Changing Drug Development
An increased understanding of disease, escalating healthcare costs and informed patient groups are having a transformative impact on the development and approvals of new therapeutics. What do pharmaceutical and biotech companies need to do to account for these changes to maximize the success of their drug development programs? (Posted: Jan 22, 2014)

The Increasing Challenges to Making New and Better Drugs
Advances in biomedical research are coming faster than ever but drug development is sputtering. What's the problem? (Posted: Oct 30, 2013)

The Microbiome, Our Health, and Other Poop
As the new fecal transplant therapy for gastrointestestinal infections has shown, the right mix of in our gut is essential for our health. As new research on the microbiome has shown, medical researchers and doctors need to pay much more attention the microbes living in and on us. (Posted: August 31, 2013)

RNA Interference (RNAi): From Drugs to GMOs
RNA interference (RNAi), discovered 15 years ago, has provided an essential tool for researchers trying to understand the function of genes. Therapeutics use of the technology has also finally made headway as the first RNAi drugs are being approved. Now, the technology is being used to make crops pest-resistant. (Posted: August, 27, 2013)

Gene Therapy Is Finally Becoming a Medical Reality
After the death of several patients during gene therapy trials at the start of the century, the approach is making a resurgence. Several promising trials are occuring. (Posted: May 7, 2012)

The 2013 Rally for Medical Research in Washington D.C.
Researchers and patients gathered to protest the declining level of funding going to the National Institutes of Health (NIH) for biomedical research to cure disease and improve healthcare. (Published: April 8, 2013)

Recent Advances in Cancer Research Gives Us Some Hope
A rundown of some recent advances that are providing hope for new and more effective treatments of breast, lung, and gastrointestinal cancers by guest writer Zach Fisher. (Posted March 30, 2013)

Providing Patient Care that Incorporates the Latest Biomedical Research
Advances in molecular analysis will revolutionize medicine, but research is advancing faster than clinics can use the information. Will patients be able to reap the benefit of new discoveries in a timely manner?

Are Science Publications Too “Old School” for 21st Century Bioscience?
Discovery in biomedical research is accelerating, but increasing complex results only trickle slowly through peer review publications to the clinic. Is there a better way?

High Throughput Drug Discovery with GPCRs
G-coupled Protein Receptors (GPCRs) are a key target for new drug discovery? Over a third of drugs target this type of biological molecule. Read about them here.

Delivering New Genes to Cure Disease
Gene therapy offers real promise for curing genetic disorders and treating a wider range diseases. How are new functional genes are put into a patients cells? This article describes the main viral DNA vectors used to make the genetic changes required for gene therapy.

Seven Areas of Focus for Research on New Cancer Therapies
What aspects of cancer are researchers focusing on to develop new cancer treatments? In the last couple decades, much has been learned about cancer cell biology. This research is providing a basis for new treatments that target the basic biology of cancer.

Pharmacokinetics: The Fate of Drugs
Pharmacokinetics is defined as the study of the action of drugs or medicines in living organisms, but it's not a simple process. There are many factors that affect how a drug reacts in living cells.

How do You Participate as a Test Subject in a Drug Trial?
Links to websites listing current and upcoming drug trials and how to become a participating subject. In addition, some sites contain new drug approval news, information on drug interactions, and clinical research job listings.

What is ACI and How is it Used to Treat Cancer?
ACI, or Active Cellular Immunotherapy is a new development in biomedical research and is being applied for treatment of cancer. Also known as Active Specific Immunotherapy.

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